Category Archives: Scientific Archive

Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative therapy for hematologic disorders, but its success is complicated by graft-versus-host disease (GvHD). Since allo-HSCT requires conditioning, tissue damaging events will occur in all patients undergoing this procedure. Chemotherapy and radiotherapy used during the conditioning regimens induce tissue damage and consequently release exogenous and endogenous molecules that […]

  In most cases, organ damage may occur following the administration of drugs used in chemotherapy and the preparation regimen for hematopoietic stem cell transplantation, total body radiotherapy (TBI), and chronic graft-versus-host disease (GVHD).    These injuries are temporary and reversible and in few cases can be life threatening. One study showed that the incidence […]

Infection is one of the common complications of patients undergoing hematopoietic stem cell transplantation (HSCT).The initial reconstruction of the immune system usually begins a few weeks after the transplantation of hematopoietic stem cells, but its complete reconstruction in terms of number and function requires months and even years. The innate immune system, such as neutrophils, […]

Definitions Historically, the term “aplastic anemia” identifies a clinical entity where patients present with anemia and an empty marrow by bone marrow (BM) biopsy. Since 1885, when Paul Ehrlich described the first case in a pregnant woman, accumulating evidence has that this complication share several clinical, histological, molecular, and biological features, and that clinically and […]

Definitions of Multiple Myeloma (MM) Multiple myeloma is a hematologic malignancy characterized by presence of abnormal clonal plasma cells in the bone marrow, with potential for uncontrolled growth causing destructive bone lesions, kidney injury, anemia, and hypercalcemia. Multiple myeloma is diagnosed in an estimated 34 920 people in the US and in approximately 588 161 people worldwide […]

Hematopoietic stem cell transplant failure: Lack of hematopoietic hematopoietic stem cells after transplantation (HSCT) is a complication that can occur during autologous and allogeneic stem cell transplantation. If the lack of hematopoiesis occurs during transplantation and before the patient is discharged from the hospital, the prognosis is not good. Several factors are known to increase […]

Adrenoleukodystrophy (ALD) is a dysfunction of one of the components of cells called peroxisome (mutation in ABCD1 gene). This rare X-linked disease is more common in men, which unfortunately cannot be predicted at birth. In adrenoleukodystrophy, there are elevated levels of long-chain fatty acids (VLCFA) in plasma due to peroxisomes beta-oxidation defects, which results in […]

Cataract is clouding of the lens of the eye, and its effect on vision is such that the affected person has a clouded vision or a bit like looking through a frozen or foggy window. Cloudy vision caused by cataracts can make it more difficult to read, drive a car (especially at night), and recognize […]