NPM1 protein (Nucleophosmin 1) is involved in several cellular processes including centrosome proliferation, chaperone role (stabilization of misfolded proteins), and cell proliferation. The produced phosphoprotein shuttles between the nucleus, nucleus and cytoplasm in the process of chaperone ribosomal proteins and histones from the nucleus nucleus to the cytoplasm. This protein also sequesters the tumor suppressor […]
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. The JAK2 gene provides instructions for making a protein that causes cells to grow and divide (multiply). This protein is part of a signaling pathway called the JAK/STAT pathway, which transmits chemical signals from the outside of the cell to the cell nucleus. The […]
From a medical point of view, the word chimera is used to define an individual in which there is a population of cells from genetically different individuals. This phenomenon can occur spontaneously, such as embryo-to-embryo transfer or embryo-to-mother transfer, or artificially in the case of allogeneic hematopoietic stem cell transplantation (HSCT). The success of allogeneic […]
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