Daily Archives: 7 آبان 1402

HLA typing HLA typing or determining the type of human leukocyte antigen (HLA) includes molecular or serological typing of blood leukocytes to determine HLA-A, -B, -C (MHC class I) and HLA- DR, DP, DQ (MHC class II). In fact, HLA typing is a process that identifies HLA molecules expressed on the surface of cells in […]

Driver mutations are mutations that play a fundamental role in activating signaling pathways in cells and lead to clinical changes in diseases. Patients with myeloproliferative neoplasms (MPN) have driver mutations in JAK2, MPL, or CALR genes, which activate the thrombopoietin receptor (TPOR) and downstream signaling pathways. JAK2 mutation is associated with permanent activation of TPOR, […]

FLT3 (fms-like tyrosine kinase 3) is a gene that provides instructions for making a protein called FLT3, which is a member of the receptor tyrosine kinase (RTKs) family of proteins. FLT3 is a cytokine receptor that belongs to the class III receptor tyrosine kinase and is expressed on the surface of many hematopoietic precursor cells. […]

The CEBPA (CCAAT/enhancer-binding protein alpha) gene encodes a protein of the same name that is important for regulating the differentiation of blood cells. This protein is a transcription factor that binds to specific regions of DNA and helps control the activity of specific genes that play a role in the growth and development of certain […]